Since it is a self-powered hub design, please connect VBUS from the CPU to the Reset pin of the hub with a RC circuit providing a delay of 10ms. This will hold the hub in reset till CPU is connected and VBUS is stable.
You could check to the 4607 DVK schematic for reference- https://www.cypress.com/file/117531/download
As I mentioned, I don't have Vbus available so can't apply the typical schematic
To solve the problem, I connected reset pin to 3.3V via a RC bridge but ommitted the second resistance for the voltage divider