For the schematic, please ensure that the crystal meets the specifications as per section 3.2 and the bulk and decoupling capacitors on the VCC pins are as per table 7 in the App Note.
-Could you please check if the OVR pin is asserted when the T261 module is connected and EN is being toggled?
-When you connect a mouse or dongle does it work independent of the port selection i.e. when these devices are connected to any port?
-Please check if the same behavior occurs when connecting the T261 on a HX2VL DVK.