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- Differential clock is optional. You can choose whether you want to use it or not. If you go to page 24 of the datasheet you will see that bit  of the Configuration Register 1 controls the master clock type. The good thing is that the default is already set to single ended clock.
- I don't think we make a level shifting recommendation here. It just needs to be fast enough to follow the signals at high speed like 200MHz which this part is able to run at. Also, if you don't have a temperature grade/speed limitation then you can choose to use the S27KL0643xxxxx020 part that supports 3.3V.
- As stated before, differential clock is not mandatory.
Thank you and Regards,