Please ensure the interrupt source for CM4 is enabled in the "Interrupt" tab of the "cydwr" file.
As mentioned in post above, please make sure that the interrupt source is checked for CM4.
Additionally, there are a few other basic checks that can be done.
1. Make sure that the CM4 is enabled by calling Cy_SysEnableCM4(CY_CORTEX_M4_APPL_ADDR); in main_cm0p.c.
2. Make sure that Global interrupts are enabled by calling __enable_irq() in main.cm4.
3. All the DMA related CEs are configured for CM4. You can refer any CE such as the PWM triggering DMA which configures the DMA for CM4.
I did all that. The SPI is triggering the DMAs. Everything is configured and enabled on the CM4.
Can you please check with one of the CEs? You could build on that. If not, would it be possible to post a minimal version of the project that you are using? With just the basic components so that we can debug the issue at our end?