Yes SMBus being a lightweight implementation of I2C should theoretically work with the PSoC as well. However, I don't believe we have tested something like this and you will probably be the first. Cannot guarantee anything at this point.
Did you try developing a script? Please do share it, if you have one, it can give us a head start on development on this regard. Will try it from our end and we can start a discussion to get this to work