As you can see from the clock settings, Clk_fast (CM4) must be a whole number multiple of Clk_slow (CM0+). Therefore it's not possible to run CM4 at 150MHz and CM0+ at 100MHz. If you want to run CM4 at it's highest frequency (150MHz), the maximum frequency of CM0+ is limited to 75MHz. Similarly, if you want to run CM0+ at 100MHz, CM4 must also run at 100MHz.
I would recommend running CM4 at 150MHz and CM0+ at 75MHz if maximum CPU performance is desired.
Please let me know if you have any additional questions.