Ap notes below may be of help -
http://www.cypress.com/?id=5509 100 Projects in 100 Days with Bluetooth
http://www.cypress.com/?rID=102512 AN91445 - Antenna Design Guide
http://www.cypress.com/?rID=102505 AN94020 - Getting Started with PRoC™ BLE
http://www.cypress.com/?rID=110007 AN92584 - Designing for Low Power and Estimating Battery Life for BLE Applications
http://www.cypress.com/?rID=109900 AN91162 - Creating a BLE Custom Profile
http://www.cypress.com/?rID=110107 AN91184 - PSoC 4 BLE - Designing BLE Applications
http://www.cypress.com/?rID=102504 AN91267 - Getting Started with PSoC® 4 BLE
With CR2032 (3.0V), a regulator is generally not needed. As Dana pointed out before, AN92584 - Designing for Low Power and Estimating Battery Life for BLE Applications would be very helpful fro your design.
Its very difficult to design a casing which prevents a user from inserting a CR2032 backwards.
I recently looked at another manufacturers BLE solution to check what happens if the battery is inserted backwards. The result was the MCU still worked (after reversal of course!) but there was no longer any radio.
A simple diode in series wont work, too much voltage drop. There are other reverse-polarity solutions but has anyone tested these ICs so check whether they are damaged by short-term reverse supply?
If you are inserting the battery backwards, then VDDA would be grounded while VSS would be powered. This can potentially damage the device. Recommended that VDDA should be the highest voltage at any instant of time.