Please check the .NET version in your system,
PSoc Creator4.0 needs .NET minimum version as 4.0
You can use the Microsoft .net recovery tool and reset the .net versions installed.
Sorry for the wait - just got back in town.
The .NET framework through 4.6 was installed and updated, or so I thought - nothing indicated any problems with the install. I've uninstalled Microsoft Visual Studio, though, and completely wiped and reinstalled .NET and it seems to have cleared up my problems in the PSoC Creator.
Thanks for the advice - I'm not sure what happened, but I'd have never suspected this to be causing problems.