You do not need a large resolution, your signal range is 5mV which would be quite enough for ECG and a resolution of 8 bits (better than 0,5%).
What you need is
- Amplification: Preferably an external instrumentation amplifier.
- Noise cancelling: could be done with the filter component (bandpass)
Most problems will come from the noise from power line at 50 or 60 Hz a sharp notch filter could help.
The required conversion frequency should be about 10 times Nyquist which in your case will be about 3kHz
Thank you very much, Bob. My another question is - if I want to use only PSoC components, so without external IA, is your suggested solution still possible?
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Yes. The PSoC5 has got 4 opamps which you might try to use for your purpose. They are not as precise as you like to have them, offset and bias are not very good, but you can give them a try. Afaik max amplification is ~50 to 100, using a second stage opamp will suffer from offset.