Please post your code so we can check it.
I took the Day011_Central_Observer example and changed the device to the CYBLE-224110, then updated the components in TopDesign.cysch to get it to build. I haven't changed anything in the code. I've attached the archived project anyway.
The '224110 is an extended-range module with PA/LNA on board. If the project does not include the code required to enable this circuitry, the RF will be effectively cut off before it reaches the antenna, causing near-complete performance degradation. I expect this is what is happening in your case.
See page 16 of the current Rev. *D of the CYBLE-224110-00 datasheet available from the product page:
It describes the steps necessary to allow correct operation of the PA/LNA circuitry on XR modules.
If only I'd read the manual properly, I'd have seen that! Thank you Jeff.
I had managed to connect to the device with CySmart and so assumed that I could use it without enabling the PA/LNA. <sigh> Yet again the lesson here is - read the manual!