Yes. The FX2 is 5 Volt tolerant on its logic inputs and drives outputs at a minimum of 2.4 Volts. You may connect inputs to pull ups of 5 volts, but you must guarantee that the input does not exceed 5.25 volts. Outputs must not exceed Vcc+0.5 volts. For a 3.3 volts, Vcc the output pull ups must not exceed 3.8 Volts.